Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice-Reference-Cited by-同舟云学术

Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice

Published:2021-02-23 Issue:1 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Shi Zunji¹²,Lei Hehua¹,Chen Gui¹³,Yuan Peihong¹,Cao Zheng¹³,Ser Hooi-Leng⁴,Zhu Xuehang¹³,Wu Fang¹³,Liu Caixiang¹,Dong Manyuan¹³,Song Yuchen¹³,Guo Yangyang¹³,Chen Chuan¹³,Hu Kexin¹³,Zhu Yifan¹,Zeng Xin-an²,Zhou Jinlin⁵,Lu Yujing⁴⁵,Patterson Andrew D.⁶^ORCID,Zhang Limin¹⁵⁷^ORCID

Affiliation:

1. Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Centre for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, CAS, Wuhan, China

2. School of Food Science and Engineering, South China University of Technology, Guangzhou, China

3. University of the Chinese Academy of Sciences, Beijing, China

4. School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China

5. Engineering Research Academy of High Value Utilization of Green Plants, Meizhou, China

6. Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, Pennsylvania, USA

7. Wuhan National Laboratory for Optoelectronics, Wuhan, China

Abstract

Our findings indicate that the gut-liver signaling axis contributes to saccharin/sucralose consumption-induced NAFLD. Supplementation with metformin or fructo-oligosaccharide is a potential therapeutic strategy for NAFLD treatment. In addition, we also developed a new nutritional strategy by using a natural sweetener (neohesperidin dihydrochalcone [NHDC]) as a substitute for NAS and free sugars.

Funder

Foshan Core Technology Tackling Key Project

National Key Research and Development Project

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00985-20

Reference58 articles.

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2. The metabolism of saccharin in laboratory animals

3. Sucralose metabolism and pharmacokinetics in man

4. Artificial Sweeteners: A Systematic Review and Primer for Gastroenterologists

5. Artificial sweeteners induce glucose intolerance by altering the gut microbiota

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