Gut Microbiota Offers Universal Biomarkers across Ethnicity in Inflammatory Bowel Disease Diagnosis and Infliximab Response Prediction

Author:

Zhou Youlian12,Xu Zhenjiang Zech345,He Yan67,Yang Yunsheng8,Liu Le1,Lin Qianyun1,Nie Yuqiang2,Li Mingsong1,Zhi Fachao1,Liu Side1,Amir Amnon3,González Antonio3,Tripathi Anupriya3,Chen Minhu9,Wu Gary D.10,Knight Rob31112,Zhou Hongwei7,Chen Ye1

Affiliation:

1. Department of Gastroenterology, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China

2. Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China

3. Department of Pediatrics, University of California, San Diego, La Jolla, California, USA

4. School of Food and Technology, Nanchang University, Nanchang, China

5. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, China

6. Department of Environmental Health, School of Public Health and Tropical Medicine, State Key Laboratory of Organ Failure Research, Southern Medical University, Guangzhou, China

7. State Key Laboratory of Organ Failure Research, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China

8. Institute of Digestive Diseases, Chinese PLA General Hospital, Beijing, China

9. Department of Gastroenterology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China

10. Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

11. Department of Computer Science and Engineering, University of California, San Diego, La Jolla, California, USA

12. Center for Microbiome Innovation, University of California, San Diego, La Jolla, California, USA

Abstract

In the present report, we show that the human fecal microbiota contains promising and universal biomarkers for the noninvasive evaluation of inflammatory bowel disease severity and IFX treatment efficacy, emphasizing the potential ability to mine the gut microbiota as a modality to stratify IBD patients and apply personalized therapy for optimal outcomes.

Funder

the National Natural Science Foundation

the Crohn's and colitis foundation of America

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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