Intermittent Hypoxia and Hypercapnia Alter Diurnal Rhythms of Luminal Gut Microbiome and Metabolome-Reference-Cited by-同舟云学术

Intermittent Hypoxia and Hypercapnia Alter Diurnal Rhythms of Luminal Gut Microbiome and Metabolome

Published:2021-06-29 Issue:3 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Allaband Celeste¹²³^ORCID,Lingaraju Amulya¹,Martino Cameron³⁴⁵^ORCID,Russell Baylee¹,Tripathi Anupriya³⁶,Poulsen Orit³,Dantas Machado Ana Carolina¹,Zhou Dan³,Xue Jin³,Elijah Emmanuel⁶,Malhotra Atul⁷,Dorrestein Pieter C.²⁶⁵,Knight Rob²³⁵⁸^ORCID,Haddad Gabriel G.²³⁹⁵,Zarrinpar Amir¹²⁵¹⁰⁷^ORCID

Affiliation:

1. Division of Gastroenterology, University of California, San Diego, La Jolla, California, USA

2. Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California, USA

3. Department of Pediatrics, University of California, San Diego, La Jolla, California, USA

4. Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, California, USA

5. Center for Microbiome Innovation, University of California, San Diego, La Jolla, California, USA

6. Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California, USA

7. Center for Circadian Biology, University of California, San Diego, La Jolla, California, USA

8. Department of Computer Science and Engineering, University of California, San Diego, La Jolla, California, USA

9. Department of Neuroscience, University of California, San Diego, La Jolla, California, USA

10. Institute of Diabetes and Metabolic Health, University of California, San Diego, La Jolla, California, USA

Abstract

People with obstructive sleep apnea, identified by loud snoring and breathing irregularly while sleeping, are at a higher risk of high blood pressure, type 2 diabetes, cardiac arrhythmias, stroke, and sudden cardiac death. We wanted to understand whether the gut microbiome changes induced by obstructive sleep apnea could potentially explain some of these medical problems.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00116-21

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