Emergence of Ciprofloxacin-Nonsusceptible Streptococcus pyogenes Isolates from Healthy Children and Pediatric Patients in Portugal-Reference-Cited by-同舟云学术

Emergence of Ciprofloxacin-Nonsusceptible Streptococcus pyogenes Isolates from Healthy Children and Pediatric Patients in Portugal

Published:2010-06 Issue:6 Volume:54 Page:2677-2680
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Pires Renato¹,Ardanuy Carmen²³,Rolo Dora¹²³,Morais Ana⁴,Brito-Avô António⁴,Gonçalo-Marques José⁵,Liñares Josefina²³,Santos-Sanches Ilda¹

Affiliation:

1. Centro de Recursos Microbiológicos (CREM), Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia (FCT), Universidade Nova de Lisboa, Caparica, Portugal

2. Microbiology Department, Institut d'Investigació Biomèdica de Bellvitge, Hospital Universitari de Bellvitge, Barcelona, Spain

3. CIBER de Enfermedades Respiratórias, ISCIII, Madrid, Spain

4. Centro de Saúde de Oeiras, Oeiras, Portugal

5. Hospital de Santa Maria, Lisbon, Portugal

Abstract

ABSTRACT We describe 66 ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates recovered from colonized and infected children. The ParC S79A substitution was frequent and associated with the emm 6/sequence type 382 ( emm 6/ST382) lineage. The ParC D83G substitution was detected in two isolates ( emm 5/ST99 and emm 28/ST52 lineages). One isolate ( emm 89/ST101) had no quinolone resistance-determining region codon substitutions or other resistance mechanisms. Five of 66 isolates were levofloxacin resistant. Although fluoroquinolones are not used in children, they may be putative disseminators of fluoroquinolone-nonsusceptible strains in the community.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01536-09

Reference29 articles.

1. Streptococcus pyogenes Pharyngeal Isolates with Reduced Susceptibility to Ciprofloxacin in Spain: Mechanisms of Resistance and Clonal Diversity

2. Alonso, R., M. Galimand, and P. Courvalin. 2004. An extended PCR-RFLP assay for detection of parC,parE and gyrA mutations in fluoroquinolone-resistant Streptococcus pneumoniae. J. Antimicrob. Chemother.53:682-683.

3. Clonal Spread of Pediatric Isolates of Ciprofloxacin-Resistant, emm Type 6 Streptococcus pyogenes

4. Biedenbach, D. J., M. A. Toleman, T. R. Walsh, and R. N. Jones. 2006. Characterization of fluoroquinolone-resistant β-hemolytic Streptococcus spp. isolated in North America and Europe including the first report of fluoroquinolone-resistant Streptococcus dysgalactiae subspecies equisimilis: report from the SENTRY Antimicrobial Surveillance Program (1997-2004). Diagn. Microbiol. Infect. Dis.55:119-127.

5. Brisse, S., and J. Verhoef. 2001. Phylogenetic diversity of Klebsiella pneumoniae and Klebsiella oxytoca clinical isolates revealed by randomly amplified polymorphic DNA, gyrA and parC genes sequencing and automated ribotyping. Int. J. Syst. Evol. Microbiol.51:915-924.

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Tackling Multidrug Resistance in Streptococci – From Novel Biotherapeutic Strategies to Nanomedicines;Frontiers in Microbiology;2020-10-06

2. Changes in Macrolide Resistance Among Group A Streptococci in Serbia and Clonal Evolution of Resistant Isolates;Microbial Drug Resistance;2018-11

3. Molecular Cloning and Docking of speB Gene Encoding Cysteine Protease With Antibiotic Interaction in Streptococcus pyogenes NBMKU12 From the Clinical Isolates;Frontiers in Microbiology;2018-08-07

4. Identification and Characterization of Fluoroquinolone Non-susceptible Streptococcus pyogenes Clones Harboring Tetracycline and Macrolide Resistance in Shanghai, China;Frontiers in Microbiology;2018-03-23

5. High prevalence of fluoroquinolone-nonsusceptible Streptococcus pyogenes emm12 in Taiwan;Diagnostic Microbiology and Infectious Disease;2015-10