Streptococcus pyogenes Pharyngeal Isolates with Reduced Susceptibility to Ciprofloxacin in Spain: Mechanisms of Resistance and Clonal Diversity-Reference-Cited by-同舟云学术

Streptococcus pyogenes Pharyngeal Isolates with Reduced Susceptibility to Ciprofloxacin in Spain: Mechanisms of Resistance and Clonal Diversity

Published:2005-01 Issue:1 Volume:49 Page:418-420
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Albertí Sebastián¹,Cortés Guadalupe¹,García-Rey Cesar²,Rubio Carmen³,Baquero Fernando⁴,García-Rodríguez José Ángel⁵,Bouza Emilio⁶,Aguilar Lorenzo²

Affiliation:

1. Institut Universitari d′Investigacions en Ciències de la Salut (IUNICS), Universitat de les Illes Balears (UIB), Palma de Mallorca

2. Departamento Médico, GlaxoSmithKline, Tres Cantos

3. Servicio de Microbiología, Hospital Lozano Blesa, Zaragoza

4. Servicio de Microbiología, Hospital Ramón y Cajal

5. Servicio de Microbiología, Hospital Clínico, Salamanca, Spain

6. Servicio de Microbiología, Hospital General Universitario Gregorio Marañón, Madrid

Abstract

ABSTRACT A survey of emm gene sequences and an analysis of the pulsed-field electrophoretic profiles of 30 Streptococcus pyogenes isolates with reduced susceptibilities to ciprofloxacin detected the prevalence of isolates with emm type 6 and considerable genetic diversity among isolates. The mechanism of ciprofloxacin resistance in these isolates was based on point mutations in topoisomerase IV subunit C encoded by parC , mainly replacement of serine-79 by alanine.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.1.418-420.2005

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