Parasite-Host Dynamics throughout Antimalarial Drug Development Stages Complicate the Translation of Parasite Clearance-Reference-Cited by-同舟云学术

Parasite-Host Dynamics throughout Antimalarial Drug Development Stages Complicate the Translation of Parasite Clearance

Published:2021-03-18 Issue:4 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Burgert Lydia¹²,Zaloumis Sophie³^ORCID,Dini Saber³^ORCID,Marquart Louise⁴,Cao Pengxing⁵,Cherkaoui Mohammed⁶,Gobeau Nathalie⁶,McCarthy James⁴^ORCID,Simpson Julie A.³,Möhrle Jörg J.¹²⁶^ORCID,Penny Melissa A.¹²^ORCID

Affiliation:

1. Swiss Tropical and Public Health Institute, Basel, Switzerland

2. University of Basel, Basel, Switzerland

3. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia

4. QIMR Berghofer Medical Research Institute, Brisbane, Australia

5. School of Mathematics and Statistics, University of Melbourne, Melbourne, Australia

6. Medicines for Malaria Venture, Geneva, Switzerland

Abstract

Ensuring continued success against malaria depends on a pipeline of new antimalarials. Antimalarial drug development utilizes preclinical murine and experimental human malaria infection studies to evaluate drug efficacy.

Funder

Swiss National Science Foundation

Australian National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01539-20

Reference51 articles.

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2. New developments in anti-malarial target candidate and product profiles

3. Antimalarial drug discovery — approaches and progress towards new medicines

4. A New In Vivo Screening Paradigm to Accelerate Antimalarial Drug Discovery

5. A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria

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