A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria

Author:

Phillips Margaret A.,White Karen L.1,Kokkonda Sreekanth2,Deng Xiaoyi,White John2,El Mazouni Farah,Marsh Kennan3,Tomchick Diana R.,Manjalanagara Krishne4,Rudra Kakali Rani4,Wirjanata Grennady5,Noviyanti Rintis6,Price Ric N.57,Marfurt Jutta5,Shackleford David M.1,Chiu Francis C. K.1,Campbell Michael1,Jimenez-Diaz Maria Belen8,Bazaga Santiago Ferrer8,Angulo-Barturen Iñigo8,Martinez Maria Santos8,Lafuente-Monasterio Maria8,Kaminsky Werner2,Silue Kigbafori9,Zeeman Anne-Marie10,Kocken Clemens10,Leroy Didier11,Blasco Benjamin11,Rossignol Emilie11,Rueckle Thomas11,Matthews Dave11,Burrows Jeremy N.11,Waterson David11,Palmer Michael J.11,Rathod Pradipsinh K.2,Charman Susan A.1

Affiliation:

1. Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia

2. Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States

3. AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064-6104, United States

4. Syngene International Ltd., 560 099 Bangalore, India

5. Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, P.O. Box 41096, Casuarina, NT 0811, Australia

6. Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, 10430 Jakarta, Indonesia

7. Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7LJ, U.K.

8. GlaxoSmithKline, Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain

9. Centre Suisse de Recherches Scientifiques en Côte d’Ivoire, Km17, Route de Dabou, Adiopodoumé, BP 1303 Abidjan, Ivory Coast

10. Biomedical Primate Research Centre, 2288 GJ Rijswijk, The Netherlands

11. Medicines for Malaria Venture, 1215 Geneva, Switzerland

Funder

Welch Foundation

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Medicines for Malaria Venture

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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