New Treatment Options against Carbapenem-Resistant Acinetobacter baumannii Infections

Author:

Isler Burcu1,Doi Yohei2,Bonomo Robert A.34,Paterson David L.5

Affiliation:

1. Istanbul Education and Research Hospital, Istanbul, Turkey

2. University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

3. Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA

4. Case Western Reserve University Veterans Affairs Center of Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA

5. The University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital Campus, Brisbane, Queensland, Australia

Abstract

Carbapenem-resistant Acinetobacter baumannii (CRAB) is a perilous nosocomial pathogen causing substantial morbidity and mortality. Current treatment options for CRAB are limited and suffer from pharmacokinetic limitations, such as high toxicity and low plasma levels.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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