Affiliation:
1. Division of Infectious Diseases, Department of Medicine, The Mount Sinai School of Medicine of the City University of New York, New York, New York 10029
Abstract
Cefamandole, a new cephalosporin derivative, was found to have a broad spectrum of activity against a cross-section of both gram-positive and gram-negative bacteria isolated from clinical material. Gram-positive cocci, except for
Streptococcus faecalis
, were very susceptible. Penicillin G-resistant
Staphylococcus aureus
also was susceptible to cefamandole. Minimal bactericidal concentrations for gram-positive cocci approximated the minimal inhibitory concentrations. Strains of
Haemophilus influenzae
were very susceptible to the drug. Most strains of
Escherichia coli, Klebsiella
sp., and
Proteus
sp. were inhibited by low concentrations. Increasing resistance occurred with larger inocula. Strains of
Pseudomonas
sp. were resistant to cefamandole.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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