Affiliation:
1. Department of Microbiology, St. Thomas's Hospital Medical School, London, S.E.1., England
Abstract
The in vitro antibacterial activity of cefamandole, a new cephalosporin antibiotic, was compared with that of cephaloridine, cephalothin, and cephalexin against 1,213 strains of gram-positive and gram-negative bacteria recently isolated from clinical sources. The decreasing order of activity of the four agents against gram-positive cocci was cephaloridine, cephalothin, cefamandole, and cephalexin. However, cefamandole was the most active of the four against
Haemophilus
species and gram-negative bacilli susceptible to cephalosporins. It was also active against many strains resistant to the other cephalosporins, such as
Enterobacter
species and indole-positive
Proteus
species, but there was a marked inoculum effect with all of these organisms, and minimal bactericidal concentrations were usually considerably higher than minimal inhibitory concentrations. Cefamandole, like other cephalosporins, had no useful activity against
Pseudomonas
species.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference3 articles.
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2. Garrod L. P. and F. O'Grady. 1971. Antibiotics and chemotherapy. E. and S. Livingstone Edinburgh and London.
3. Outbreak of hospital infection caused by contaminated autoclaved fluids;Phillips I.;Lancet,1972
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