Prevention of Herpes Keratoconjunctivitis in Rabbits By Silver Sulfadiazine

Author:

Chang Te-Wen1,Weinstein Louis

Affiliation:

1. Infectious Disease Service, New England Medical Center Hospital and the Peter Bent Brigham Hospital, Boston, Massachusetts 02111

Abstract

Silver sulfadiazine, at a concentration of 10 μg/ml when applied immediately after infection by Herpesvirus hominis , prevented the development of acute herpetic keratoconjunctivitis in rabbits. The efficacy was inversely related to the size of inoculum. Subclinical infections were observed in the drug-treated eyes.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference7 articles.

1. Baxter C. R. 1971. Topical use of 0.1% silver sulfadiazine p. 217-225. In H. C. Polk and H. H. Stone (ed.) Contemporary burn management. Little Brown and Co. Boston.

2. In vitro antiherpesviral activity of silver sulfadiazine;Chang T. W.;J. Infect. Dis.,1975

3. Inactivation of Treponema pallidum by silver sulfadiazine;Chang T. W.;Antimicrob. Agents Chemother.,1975

4. Inactivation of herpesvirus hominis type 1 and 2 by silver nitrate in vitro and in vivo;Coleman W. R.;Antimicrob. Agents Chemother.,1973

5. Silver sulfadiazine-new topical therapy for pseudomonas in burns;Fox L. L.;Arch. Surg.,1968

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