Affiliation:
1. Infectious Diseases Service of the New England Medical Center Hospital Department of Medicine, Tufts University School of Medicine, and Harvard Medical School, Boston, Massachusetts 02111
Abstract
Silver sulfadiazine, an anti-infectious agent for the prevention and treatment of burn sepsis, has been found to possess antitreponemal activity against
Treponema pallidum
. At 28 C, complete inactivation of the organism was produced by exposure of the organism to a concentration of 50 μg of the drug per ml for 1 to 5 min, 12 to 25 μg/ml for 10 to 15 min, and 6.2 μg/ml for 30 min. At 37 C, the amounts of silver sulfadiazine required for inactivation were two- to fourfold less.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference5 articles.
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4. Immunity to syphilis. I. Passive transfer in rabbits with hyperimmune serum;Perine P. L.;Infect. Immun.,1973
5. Antifungal activity of silver sulfadiazine;Wlodkowski T. J.;Lancet,1973
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