Identification of Conserved Candidate Vaccine Antigens in the Surface Proteome of Giardia lamblia

Author:

Davids Barbara J.1,Liu Ching M.1,Hanson Elaine M.1,Le Christine H. Y.1,Ang Jonathan1,Hanevik Kurt2,Fischer Marvin2,Radunovic Matej1,Langeland Nina2,Ferella Marcela3,Svärd Staffan G.3,Ghassemian Majid4,Miyamoto Yukiko1,Eckmann Lars1

Affiliation:

1. Department of Medicine, University of California, San Diego, La Jolla, California, USA

2. Department of Clinical Science, University of Bergen, Bergen, Norway

3. Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden

4. Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA

Abstract

Giardia lamblia , one of the most common protozoal infections of the human intestine, is an important worldwide cause of diarrheal disease, malabsorption, malnutrition, delayed cognitive development in children, and protracted postinfectious syndromes. Despite its medical importance, no human vaccine is available against giardiasis.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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