Desialylation of Platelets by Pneumococcal Neuraminidase A Induces ADP-Dependent Platelet Hyperreactivity-Reference-Cited by-同舟云学术

Desialylation of Platelets by Pneumococcal Neuraminidase A Induces ADP-Dependent Platelet Hyperreactivity

Published:2018-10 Issue:10 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Kullaya Vesla¹²³,de Jonge Marien I.²⁴,Langereis Jeroen D.²⁴^ORCID,van der Gaast-de Jongh Christa E.²⁴,Büll Christian⁵,Adema Gosse J.⁵,Lefeber Dirk⁶,Cremers Amelieke J.⁷,Mmbaga Blandina T.³,de Groot Phillip G.⁸,de Mast Quirijn¹²,van der Ven Andre J.¹²

Affiliation:

1. Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

2. Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

3. Kilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical Centre, Moshi, Tanzania

4. Laboratory of Pediatric Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands

5. Department of Radiation Oncology, Radiotherapy and Oncoimmunology Laboratory, Radboud University Medical Center, Nijmegen, The Netherlands

6. Translational Metabolic Laboratory, Radboud University Medical Center, Nijmegen, The Netherlands

7. Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands

8. Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, The Netherlands

Abstract

Platelets are increasingly recognized to play a role in the complications of Streptococcus pneumoniae infections. S. pneumoniae expresses neuraminidases, which may alter glycans on the platelet surface.

Funder

Netherlands Fellowship Programme

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00213-18

Reference51 articles.

1. The innate immune response to pneumococcal lung infection: the untold story

2. Amplification of bacteria-induced platelet activation is triggered by FcγRIIA, integrin αIIbβ3, and platelet factor 4

3. Invasive Streptococcus pneumoniae trigger platelet activation via Toll-like receptor 2