Amplification of bacteria-induced platelet activation is triggered by FcγRIIA, integrin αIIbβ3, and platelet factor 4-Reference-Cited by-同舟云学术

Amplification of bacteria-induced platelet activation is triggered by FcγRIIA, integrin αIIbβ3, and platelet factor 4

Published:2014-05-15 Issue:20 Volume:123 Page:3166-3174
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Arman Mònica¹,Krauel Krystin²³,Tilley Dorothea O.⁴,Weber Claudia⁵,Cox Dermot⁴,Greinacher Andreas²,Kerrigan Steven W.⁴,Watson Steve P.¹

Affiliation:

1. Centre for Cardiovascular Sciences, Institute of Biomedical Research, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom;

2. Institut für Immunologie und Transfusionsmedizin, Universitätsmedizin Greifswald, Greifswald, Germany;

3. Zentrum für Innovationskompetenz–Humorale Immunreaktionen bei Kardiovaskulären Erkrankungen, Universitätsmedizin Greifswald, Greifswald, Germany;

4. Cardiovascular Infection Group, Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland; and

5. Abteilung Genetik der Mikroorganismen, Interfakultäres Institut für Genetik und Funktionelle Genomforschung, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany

Abstract

Key Points FcγRIIA activation is key for platelet aggregation in response to bacteria, and depends on IgG and αIIbβ3 engagement. PF4 binds to bacteria and reduces the lag time for platelet aggregation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/20/3166/1376750/3166.pdf

Reference48 articles.

1. Platelets and the immune continuum.;Semple;Nat Rev Immunol,2011

2. Thrombosis as an intravascular effector of innate immunity.;Engelmann;Nat Rev Immunol,2013

3. Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance.;Wong;Nat Immunol,2013

4. Platelets and the innate immune system: mechanisms of bacterial-induced platelet activation.;Cox;J Thromb Haemost,2011

5. Cardiovascular disease and periodontitis: an update on the associations and risk.;Persson;J Clin Periodontol,2008

Cited by 129 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Biofilm-dispersed pneumococci induce elevated leukocyte and platelet activation;Frontiers in Cellular and Infection Microbiology;2024-08-01

2. Iron deficiency anemia and platelet dysfunction: A comprehensive analysis of the underlying mechanisms;Life Sciences;2024-08

3. Modulation of Staphylococcus aureus gene expression during proliferation in platelet concentrates with focus on virulence and platelet functionality;PLOS ONE;2024-07-25

4. Insights into the writing process of the mask-free nanoprinting fluid force microscopy technology;Measurement Science and Technology;2024-05-22

5. Platelets: Orchestrators of immunity in host defense and beyond;Immunity;2024-05