Role of DNA Repair by Nonhomologous-End Joining in Bacillus subtilis Spore Resistance to Extreme Dryness, Mono- and Polychromatic UV, and Ionizing Radiation-Reference-Cited by-同舟云学术

Role of DNA Repair by Nonhomologous-End Joining in Bacillus subtilis Spore Resistance to Extreme Dryness, Mono- and Polychromatic UV, and Ionizing Radiation

Published:2007-04-15 Issue:8 Volume:189 Page:3306-3311
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Moeller Ralf¹²,Stackebrandt Erko²,Reitz Günther¹,Berger Thomas¹,Rettberg Petra¹,Doherty Aidan J.³,Horneck Gerda¹,Nicholson Wayne L.⁴

Affiliation:

1. German Aerospace Center, Institute of Aerospace Medicine, Radiation Biology Division, Research Group Photo- and Exobiology, Cologne, Germany

2. German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany

3. Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, United Kingdom

4. Department of Microbiology and Cell Science, University of Florida, Kennedy Space Center, Florida 32899

Abstract

ABSTRACT The role of DNA repair by nonhomologous-end joining (NHEJ) in spore resistance to UV, ionizing radiation, and ultrahigh vacuum was studied in wild-type and DNA repair mutants ( recA , splB , ykoU , ykoV , and ykoU ykoV mutants) of Bacillus subtilis . NHEJ-defective spores with mutations in ykoU , ykoV , and ykoU ykoV were significantly more sensitive to UV, ionizing radiation, and ultrahigh vacuum than wild-type spores, indicating that NHEJ provides an important pathway during spore germination for repair of DNA double-strand breaks.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00018-07

Reference58 articles.

1. Aravind, L., and E. V. Koonin. 2001. Prokaryotic homologues of eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a prokaryotic double-strand break repair system. Genome Res. 11 : 1365-1374.

2. Baltschukat, K., G. Horneck, H. Bücker, R. Facius, and M. Schäfer. 1986. Mutation induction in spores of Bacillus subtilis by accelerated very heavy ions. Radiat. Environ. Biophys. 25 : 183-187.

3. Bowater, R., and A. J. Doherty. 2006. Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining. PLOS Genet. 2 : e8-e15.

4. Buis, J. M., J. Cheek, E. Kalliri, and J. B. Broderick. 2006. Characterization of an active spore photoproduct lyase, a DNA repair enzyme in the radical S-adenosylmethionine superfamily. J. Biol. Chem. 281 : 25994-26003.

5. Cano, R. J., and M. K. Borucki. 1995. Revival and identification of bacterial spores in 25- to 40-million-year-old Dominican amber. Science 268 : 1060-1064.

Cited by 133 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Mechanism of microbial spore inactivation through electromagnetic radiations: a review;Journal of Future Foods;2024-12

2. Bacillus subtilis stress-associated mutagenesis and developmental DNA repair;Microbiology and Molecular Biology Reviews;2024-06-27

3. Mechanistic Characterization of De Novo Generation of Variable Number Tandem Repeats in Circular Plasmids during Site‐Directed Mutagenesis and Optimization for Coding Gene Application;Advanced Biology;2024-06-16

4. Planetary Protection Knowledge Gap Closure Enabling Crewed Missions to Mars;Astrobiology;2024-03-01

5. Overview and Applications of CRISPR/Cas9 Based Genome Editing in Industrial Microorganisms;Genome Editing in Bacteria (Part 1);2024-02-12