Coupling of Human Circadian and Cell Cycles by the Timeless Protein-Reference-Cited by-同舟云学术

Coupling of Human Circadian and Cell Cycles by the Timeless Protein

Published:2005-04-15 Issue:8 Volume:25 Page:3109-3116
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Ünsal-Kaçmaz Keziban¹,Mullen Thomas E.²,Kaufmann William K.³,Sancar Aziz¹

Affiliation:

1. Department of Biochemistry and Biophysics

2. Cancer Cell Biology Training Program

3. Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina

Abstract

ABSTRACT The Timeless protein is essential for circadian rhythm in Drosophila . The Timeless orthologue in mice is essential for viability and appears to be required for the maintenance of a robust circadian rhythm as well. We have found that the human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein.

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.25.8.3109-3116.2005

Reference43 articles.

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