Anidulafungin Pharmacokinetics in Ascites Fluid and Pleural Effusion of Critically Ill Patients-Reference-Cited by-同舟云学术

Anidulafungin Pharmacokinetics in Ascites Fluid and Pleural Effusion of Critically Ill Patients

Published:2018-04 Issue:4 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Welte R.¹,Eller P.²,Lorenz I.³,Joannidis M.⁴,Bellmann R.¹

Affiliation:

1. Clinical Pharmacokinetics Unit, Division of Intensive Care and Emergency Medicine, Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, Austria

2. Department of Internal Medicine, Medical University of Graz, Graz, Austria

3. General and Surgical ICU, Department of General and Surgical Intensive Care Medicine, Center of Operative Medicine, Medical University of Innsbruck, Innsbruck, Austria

4. Division of Intensive Care and Emergency Medicine, Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, Austria

Abstract

ABSTRACT Anidulafungin concentrations were quantified with high-pressure liquid chromatography (HPLC) and UV detection of the ascites fluid and pleural effusion of 10 adult critically ill patients. Samples were collected from ascites fluid and from pleural drains or during paracentesis and thoracentesis, respectively. Anidulafungin levels in ascites fluid (0.12 to 0.99 μg/ml) and in pleural effusion (0.32 to 2.02 μg/ml) were below the simultaneous levels in plasma (1.04 to 7.70 and 2.48 to 13.36 μg/ml, respectively) and below the MIC values for several pathogenic Candida strains.

Funder

Pfizer Inc.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02326-17

Reference20 articles.

1. Executive Summary: Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America

2. Fungal empyema thoracis in cancer patients

3. CandidaEmpyema Thoracis at a Hospital in Taiwan