Intracellular Penetration and Activity of DX-619 in Human Polymorphonuclear Leukocytes-Reference-Cited by-同舟云学术

Intracellular Penetration and Activity of DX-619 in Human Polymorphonuclear Leukocytes

Published:2006-09 Issue:9 Volume:50 Page:3173-3174
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

García Isabel¹,Ballesta Sofía¹,Murillo Concepción²,Perea Evelio J.¹²,Pascual Álvaro¹²

Affiliation:

1. Dept. of Microbiology, School of Medicine, University of Seville

2. Dept. of Microbiology, University Hospital Virgen Macarena, Seville, Spain

Abstract

ABSTRACT The intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes have been evaluated. DX-619 reached intracellular concentrations 10 times higher than the extracellular concentrations reached. Uptake was rapid, reversible, nonsaturable, and affected by environmental temperature, some metabolic inhibitors, and a soluble membrane activator. DX-619 showed intracellular activity against Staphylococcus aureus .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00427-06

Reference17 articles.

1. Baltch, A. L., L. H. Bopp, R. P. Smith, P. B. Michelsen, and W. J. Ritz. 2005. Antibacterial activities of gemifloxacin, levofloxacin, gatifloxacin, moxifloxacin and erythromycin against intracellular Legionella pneumophila and Legionella micdadei in human monocytes. J. Antimicrob. Chemother.56:104-109.

2. Antistaphylococcal Activity of DX-619, a New Des-F(6)-Quinolone, Compared to Those of Other Agents

3. InVitro Antibacterial Activity of DX-619, a Novel Des-Fluoro(6) Quinolone

4. In Vivo Efficacies and Pharmacokinetics of DX-619, a Novel Des-Fluoro(6) Quinolone, against Streptococcus pneumoniae in a Mouse Lung Infection Model

5. Uptake and intracellular activity of sparfloxacin in human polymorphonuclear leukocytes and tissue culture cells

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