Pooled Multicenter Analysis of Cardiovascular Safety and Population Pharmacokinetic Properties of Piperaquine in African Patients with Uncomplicated Falciparum Malaria-Reference-Cited by-同舟云学术

Pooled Multicenter Analysis of Cardiovascular Safety and Population Pharmacokinetic Properties of Piperaquine in African Patients with Uncomplicated Falciparum Malaria

Published:2020-06-23 Issue:7 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wattanakul Thanaporn¹²,Ogutu Bernhards³⁴,Kabanywanyi Abdunoor M.⁵,Asante Kwaku-Poku⁶,Oduro Abraham⁷,Adjei Alex⁸,Sie Ali⁹,Sevene Esperanca¹⁰,Macete Eusebio¹⁰,Compaore Guillaume⁹,Valea Innocent¹¹,Osei Isaac⁷,Winterberg Markus¹²,Gyapong Margaret⁸¹²,Adjuik Martin³,Abdulla Salim⁵,Owusu-Agyei Seth⁶¹²,White Nicholas J.¹²,Day Nicholas P. J.¹²,Tinto Halidou¹¹,Baiden Rita³,Binka Fred³¹²,Tarning Joel¹²¹³^ORCID

Affiliation:

1. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

2. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

3. INDEPTH Network, Accra, Ghana

4. Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

5. Ifakara Health Institute, Ifakara, Tanzania

6. Kintampo Health Research Centre, Kintampo, Ghana

7. Navrongo Health Research Centre, Navrongo, Ghana

8. Dodowa Health Research Centre, Dodowa, Ghana

9. Nouna Health Research Centre, Nouna, Burkina Faso

10. Centro de Investigaçãoem Saúde de Manhiça, CISM, Manhiça, Mozambique

11. Clinical Research Unit of Nanoro (IRSS-URCN), Nanoro, Burkina Faso

12. University for Health and Allied Sciences, Ho, Ghana

13. WorldWide Antimalarial Resistance Network, Oxford, United Kingdom

Abstract

Dihydroartemisinin-piperaquine has shown excellent efficacy and tolerability in malaria treatment. However, concerns have been raised of potentially harmful cardiotoxic effects associated with piperaquine. The population pharmacokinetics and cardiac effects of piperaquine were evaluated in 1,000 patients, mostly children enrolled in a multicenter trial from 10 sites in Africa. A linear relationship described the QTc-prolonging effect of piperaquine, estimating a 5.90-ms mean QTc prolongation per 100-ng/ml increase in piperaquine concentration.

Funder

Wellcome Trust

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01848-19

Reference45 articles.

1. World Trade Report 2018

2. Treatment outcomes in a safety observational study of dihydroartemisinin/piperaquine (Eurartesim®) in the treatment of uncomplicated malaria at public health facilities in four African countries