Cardiovascular concentration–effect relationships of amodiaquine and its metabolite desethylamodiaquine: Clinical and preclinical studies

Author:

Chan Xin Hui S.12ORCID,Chotsiri Palang1ORCID,Capel Rebecca A.3,Pike James1,Hanboonkunupakarn Borimas14,Lee Sue J.12,Hanafiah Maryam1,Win Yan Naung15,Cremer Maegan A.3,Kiechel Jean‐René6,Ogutu Bernhards7,Taylor Walter R. J.12,Burton Rebecca‐Ann B.3,Tarning Joel128ORCID,White Nicholas J.12ORCID

Affiliation:

1. Mahidol‐Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine Mahidol University Bangkok Thailand

2. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine University of Oxford Oxford UK

3. Department of Pharmacology University of Oxford Oxford UK

4. Department of Clinical Tropical Medicine, Faculty of Tropical Medicine Mahidol University Bangkok Thailand

5. Department of Preventive and Social Medicine University of Medicine Taunggyi Myanmar

6. Drug for Neglected Diseases Initiative Geneva Switzerland

7. Kenya Medical Research Institute Kisumu Kenya

8. WorldWide Antimalarial Research Network, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine University of Oxford Oxford UK

Funder

Wellcome Trust

Medical Research Council

Royal Society

British Heart Foundation

Bill and Melinda Gates Foundation

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference58 articles.

1. Aminoalkylphenols as Antimalarials. II.1 (Heterocyclic-amino)-α-amino-o-cresols. The Synthesis of Camoquin2

2. World Health Organization.Guidelines for the treatment of malaria. 3rd ed. Geneva Switzerland;2015.

3. World Health Organization.World malaria report 2019. Geneva Switzerland 2019. doi:10.30875/7e6f8c91‐en.

4. World Health Organization.Seasonal malaria chemoprevention with sulfadoxine‐pyrimethamine plus amodiaquine in children: a field guide. Geneva Switzerland 2013.

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