Regulation of BRCA1 Transcription by Specific Single-Stranded DNA Binding Factors-Reference-Cited by-同舟云学术

Regulation of BRCA1 Transcription by Specific Single-Stranded DNA Binding Factors

Published:2003-06 Issue:11 Volume:23 Page:3774-3787
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Thakur Sanjay¹,Nakamura Tatsuya¹,Calin George¹,Russo Andrea¹,Tamburrino Joseph F.¹,Shimizu Masayoshi¹,Baldassarre Gustavo¹,Battista Sabrina¹,Fusco Alfredo²,Wassell Richard P.¹,Dubois Garret¹,Alder Hansjuerg¹,Croce Carlo M.¹

Affiliation:

1. Kimmel Cancer Center, Philadelphia, Pennsylvania 19107

2. Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, 80131 Naples, Italy

Abstract

ABSTRACT Since the majority of high-grade breast cancers express reduced levels of BRCA1 mRNA, we investigated the factors regulating BRCA1 transcription. Factors with specific affinity for the previously identified positive regulatory region (PRR) in the BRCA1 promoter were purified from whole-cell extracts. Identified proteins included replication protein A and a series of related factors with affinity for the sense strand of PRR. A subset of the identified factors activated the BRCA1 promoter. Identification of these families of proteins regulating the BRCA1 promoter represents an important step in the comprehension of the mechanisms responsible for breast cancer development.

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.23.11.3774-3787.2003

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