Modulation of the Gut Microbiota during High-Dose Glycerol Monolaurate-Mediated Amelioration of Obesity in Mice Fed a High-Fat Diet-Reference-Cited by-同舟云学术

Modulation of the Gut Microbiota during High-Dose Glycerol Monolaurate-Mediated Amelioration of Obesity in Mice Fed a High-Fat Diet

Published:2020-04-28 Issue:2 Volume:11 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Zhao Minjie¹²³⁴⁵,Jiang Zengliang⁶,Cai Haiying⁷,Li Yang⁸,Mo Qiufen¹²³⁴⁵,Deng Lingli¹²³⁴⁵,Zhong Hao¹²³⁴⁵,Liu Tao¹²³⁴⁵,Zhang Hui¹²³⁴⁵,Kang Jing X.⁹¹⁰,Feng Fengqin¹²³⁴⁵

Affiliation:

1. College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, China

2. National Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang University, Hangzhou, China

3. Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture, Zhejiang University, Hangzhou, China

4. Key Laboratory for Agro-Products Nutritional Evaluation of Ministry of Agriculture, Zhejiang University, Hangzhou, China

5. Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, China

6. Institute of Basic Medical Sciences, School of Life Sciences, Westlake University, Hangzhou, China

7. Zhejiang Key Lab for Chem & Bio Processing Technology of Farm Product, Zhejiang University of Science and Technology, Hangzhou, China

8. College of Food Science and Engineering, Qingdao Agricultural University, Qingdao, China

9. Laboratory of Lipid Medicine and Technology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA

10. Harvard Medical School, Boston, Massachusetts, USA

Abstract

Obesity and associated metabolic disorders are worldwide public health issues. The gut microbiota plays a key role in the pathophysiology of diet-induced obesity. Glycerol monolaurate (GML) is a widely consumed food emulsifier with antibacterial properties. Here, we explore the anti-obesity effect of GML (1,600 mg/kg of body weight) in high-fat diet (HFD)-fed mice. HFD-fed mice were treated with 1,600 mg/kg GML. Integrated microbiome, metabolome, and transcriptome analyses were used to systematically investigate the metabolic effects of GML, and antibiotic treatment was used to assess the effects of GML on the gut microbiota.

Funder

Technology and achievement transformation project of hangzhou

Zhejiang university new rural development research institute agricultural technology promotion fund

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00190-20

Reference67 articles.