Substrate-Dependent Utilization of OprM or OpmH by the Pseudomonas aeruginosa MexJK Efflux Pump-Reference-Cited by-同舟云学术

Substrate-Dependent Utilization of OprM or OpmH by the Pseudomonas aeruginosa MexJK Efflux Pump

Published:2005-05 Issue:5 Volume:49 Page:2133-2136
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chuanchuen Rungtip¹,Murata Takeshi²,Gotoh Naomasa²,Schweizer Herbert P.³

Affiliation:

1. Department of Veterinary Public Health, Faculty of Veterinary Science, Chulalongkorn University, Patumwan, Bangkok, 10330, Thailand

2. Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto, 6078414, Japan

3. Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523

Abstract

ABSTRACT MexJK requires OprM for erythromycin efflux but not for triclosan efflux. Deletion of 15 OprM family outer membrane proteins (OMPs) revealed that only the TolC homolog OpmH functions with MexJK for triclosan efflux. This is the first report of natural utilization of multiple OMPs by a given resistance nodulation cell division transporter/membrane fusion protein pair.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.5.2133-2136.2005

Reference26 articles.

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3. Chuanchuen, R., R. R. Karkhoff-Schweizer, and H. P. Schweizer. 2003. High-level triclosan resistance in Pseudomonas aeruginosa is solely due to efflux. Am. J. Infect. Control31:124-127.

4. The MexJK Efflux Pump of Pseudomonas aeruginosa Requires OprM for Antibiotic Efflux but Not for Efflux of Triclosan

5. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products

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