Aspirin Modulation of the Colorectal Cancer-Associated Microbe Fusobacterium nucleatum

Author:

Brennan Caitlin A.12,Nakatsu Geicho12,Gallini Comeau Carey Ann1,Drew David A.34,Glickman Jonathan N.56,Schoen Robert E.7,Chan Andrew T.12348,Garrett Wendy S.128910

Affiliation:

1. Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA

2. Harvard T. H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA

3. Clinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA

4. Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA

5. Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA

6. Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

7. Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

8. Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA

9. Department and Division of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA

10. Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA

Abstract

There is an increasing understanding of the clinical correlations and potential mechanistic roles of specific members of the gut and tumoral microbiota in colorectal cancer (CRC) initiation, progression, and survival. However, we have yet to parlay this knowledge into better CRC outcomes through microbially informed diagnostic, preventive, or therapeutic approaches.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Cancer Research UK

Damon Runyon Cancer Research Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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