Escherichia coli Induces DNA Double-Strand Breaks in Eukaryotic Cells-Reference-Cited by-同舟云学术

Escherichia coli Induces DNA Double-Strand Breaks in Eukaryotic Cells

Published:2006-08-11 Issue:5788 Volume:313 Page:848-851
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Nougayrède Jean-Philippe¹²³⁴,Homburg Stefan¹²³⁴,Taieb Frédéric¹²³⁴,Boury Michèle¹²³⁴,Brzuszkiewicz Elzbieta¹²³⁴,Gottschalk Gerhard¹²³⁴,Buchrieser Carmen¹²³⁴,Hacker Jörg¹²³⁴,Dobrindt Ulrich¹²³⁴,Oswald Eric¹²³⁴

Affiliation:

1. INRA, UMR1225, Ecole Nationale Vétérinaire de Toulouse, Toulouse F-31076, France.

2. Institut für Molekulare Infektionsbiologie, Universität Würzburg, Würzburg D-97070, Germany.

3. Göttingen Genomics Laboratory, Universität Göttingen, Göttingen D-37077, Germany.

4. Institut Pasteur, Unité de Génomique des Microorganismes Pathogènes and CNRS URA 2171, Paris F-75724, France.

Abstract

Transient infection of eukaryotic cells with commensal and extraintestinal pathogenic Escherichia coli of phylogenetic group B2 blocks mitosis and induces megalocytosis. This trait is linked to a widely spread genomic island that encodes giant modular nonribosomal peptide and polyketide synthases. Contact with E. coli expressing this gene cluster causes DNA double-strand breaks and activation of the DNA damage checkpoint pathway, leading to cell cycle arrest and eventually to cell death. Discovery of hybrid peptide-polyketide genotoxins in E. coli will change our view on pathogenesis and commensalism and open new biotechnological applications.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

1. Pathogenic Escherichia coli

2. Prokaryotic Chromosomes and Disease

3. Exploitation of Mammalian Host Cell Functions by Bacterial Pathogens

4. Cyclomodulins: bacterial effectors that modulate the eukaryotic cell cycle

5. A Bacterial Toxin That Controls Cell Cycle Progression as a Deoxyribonuclease I-Like Protein

Cited by 909 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. L-tryptophan and copper interactions linked to reduced colibactin genotoxicity in pks+ Escherichia coli;mSystems;2024-09-12

2. Orally Ingested Micro- and Nano-Plastics: A Hidden Driver of Inflammatory Bowel Disease and Colorectal Cancer;Cancers;2024-09-04

3. Benefits and concerns of probiotics: an overview of the potential genotoxicity of the colibactin-producing Escherichia coli Nissle 1917 strain;Gut Microbes;2024-09-04

4. Repair of genomic interstrand crosslinks;DNA Repair;2024-09

5. Relevance of harmful intratumoral microbiota in cancer progression and its clinical application;Biomedicine & Pharmacotherapy;2024-09