SRI-286, a Thiosemicarbazole, in Combination with Mefloquine and Moxifloxacin for Treatment of Murine Mycobacterium avium Complex Disease-Reference-Cited by-同舟云学术

SRI-286, a Thiosemicarbazole, in Combination with Mefloquine and Moxifloxacin for Treatment of Murine Mycobacterium avium Complex Disease

Published:2004-09 Issue:9 Volume:48 Page:3556-3558
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bermudez Luiz E.¹²³,Kolonoski Peter¹,Seitz Lianne E.⁴,Petrofsky Mary¹,Reynolds Robert⁴,Wu Martin¹²,Young Lowell S.¹

Affiliation:

1. Kuzell Institute, California Pacific Medical Center Research Institute, San Francisco, California

2. Department of Biomedical Science, College of Veterinary Medicine

3. Department of Microbiology, College of Science, Oregon State University, Corvallis, Oregon

4. Southern Research Institute, Birmingham, Alabama

Abstract

ABSTRACT Treatment of Mycobacterium avium disease remains challenging when macrolide resistance develops. We infected C57 beige mice and treated them with mefloquine, SRI-286, and moxifloxacin. SRI-286 (80 mg/kg) was bactericidal in the liver. Mefloquine plus moxifloxacin or mefloquine plus SRI-286 were better than mefloquine alone.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.9.3556-3558.2004

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