Thiosemicarbazole (Thiacetazone-Like) Compound with Activity against Mycobacterium avium in Mice-Reference-Cited by-同舟云学术

Thiosemicarbazole (Thiacetazone-Like) Compound with Activity against Mycobacterium avium in Mice

Published:2003-08 Issue:8 Volume:47 Page:2685-2687
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bermudez Luiz E.¹²,Reynolds Robert³,Kolonoski Peter¹,Aralar Pricilla⁴,Inderlied Clark B.⁴⁵,Young Lowell S.¹

Affiliation:

1. Kuzell Institute for Arthritis and Infectious Diseases, California Pacific Medical Center Research Institute, San Francisco, California 94115

2. Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon 97331

3. Southern Research Institute, Birmingham, Alabama

4. Children's Hospital of Los Angeles

5. University of Southern California, Los Angeles, California

Abstract

ABSTRACT In vitro screening of thiacetazone derivatives indicated that two derivatives, SRI-286 and SRI-224, inhibited a panel of 25 Mycobacterium avium complex (MAC) isolates at concentrations of 2 μg/ml or lower. In mice, SRI-224 and thiacetazone had no significant activity against the MAC in livers and spleens, but treatment with SRI-286 resulted in significant reduction of bacterial loads in livers and spleens. A combination of SRI-286 and moxifloxacin was significantly more active than single drug regimens in liver and spleen.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.8.2685-2687.2003

Reference17 articles.

1. Activity of Moxifloxacin by Itself and in Combination with Ethambutol, Rifabutin, and Azithromycin In Vitro and In Vivo against Mycobacterium avium

2. Telithromycin Is Active against Mycobacterium avium in Mice despite Lacking Significant Activity in Standard In Vitro and Macrophage Assays and Is Associated with Low Frequency of Resistance during Treatment

3. Roxithromycin alone and in combination with either ethambutol or levofloxacin for disseminated Mycobacterium avium infections in beige mice

4. Bertram, M. A., C. B. Inderlied, S. Yadegar, P. Kolanoski, J. K. Yamada, and L. S. Young. 1986. Confirmation of the beige mouse model for study of disseminated infection with Mycobacterium avium complex. J. Infect. Dis.154:194-195.

5. Chaisson, R. E., C. A. Benson, M. P. Dube, L. B. Heifets, J. A. Korvick, S. Elkin, T. Smith, J. C. Craft, F. R. Sattler, et al. 1994. Clarithromycin therapy for bacteremic Mycobacterium avium complex disease. A randomized, double-blind, dose-ranging study in patients with AIDS. Ann. Intern. Med.121:905-911.

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