T2182C Mutation in 23S rRNA Is Associated with Clarithromycin Resistance in Helicobacter pylori Isolates Obtained in Bangladesh-Reference-Cited by-同舟云学术

T2182C Mutation in 23S rRNA Is Associated with Clarithromycin Resistance in Helicobacter pylori Isolates Obtained in Bangladesh

Published:2004-09 Issue:9 Volume:48 Page:3567-3569
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Khan Rasel¹,Nahar Shamsun¹,Sultana Jinath¹,Ahmad Mian Mashhud²,Rahman Motiur¹

Affiliation:

1. Laboratory Sciences Division, ICDDR, B: Centre for Health and Population Research

2. Dhaka Medical College Hospital, Dhaka, Bangladesh

Abstract

ABSTRACT Twelve clarithromycin-resistant (MIC, ≥1 μg/ml) Helicobacter pylori isolates were analyzed for point mutations in the 23S rRNA gene. Sequence analysis of all of the resistant isolates revealed a T-to-C transition mutation at position 2182. Transformation experiments confirmed that a single T-to-C transition mutation at position 2182 is associated with clarithromycin resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.9.3567-3569.2004

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