Stability of erp Loci during Borrelia burgdorferi Infection: Recombination Is Not Required for Chronic Infection of Immunocompetent Mice-Reference-Cited by-同舟云学术

Stability of erp Loci during Borrelia burgdorferi Infection: Recombination Is Not Required for Chronic Infection of Immunocompetent Mice

Published:1999-06 Issue:6 Volume:67 Page:3146-3150
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

El Hage Nazira¹,Lieto Louis D.²,Stevenson Brian¹

Affiliation:

1. Department of Microbiology and Immunology, University of Kentucky College of Medicine, Lexington, Kentucky, 40536-0084,1 and

2. Department of Veterinary Science, University of Kentucky, Lexington, Kentucky 40536-00762

Abstract

ABSTRACT Borrelia burgdorferi can persistently infect mammals despite their production of antibodies directed against bacterial proteins, including the Erp lipoproteins. We sequenced erp loci of bacteria reisolated from laboratory mice after 1 year of infection and found them to be identical to those of the inoculant bacteria. We conclude that recombination of erp genes is not essential for chronic mammalian infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.67.6.3146-3150.1999

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