The Consistent Tick-Vertebrate Infectious Cycle of the Lyme Disease Spirochete Enables Borrelia burgdorferi To Control Protein Expression by Monitoring Its Physiological Status-Reference-Cited by-同舟云学术

The Consistent Tick-Vertebrate Infectious Cycle of the Lyme Disease Spirochete Enables Borrelia burgdorferi To Control Protein Expression by Monitoring Its Physiological Status

Published:2022-05-17 Issue:5 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Stevenson Brian¹²,Krusenstjerna Andrew C.¹,Castro-Padovani Tatiana N.¹,Savage Christina R.¹,Jutras Brandon L.³,Saylor Timothy C.¹

Affiliation:

1. Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky, USA

2. Department of Entomology, University of Kentucky, Lexington, Kentucky, USA

3. Department of Biochemistry, Virginia Tech, Blacksburg, Virginia, USA

Abstract

The Lyme disease spirochete, Borrelia burgdorferi , persists in nature by alternatingly cycling between ticks and vertebrates. During each stage of the infectious cycle, B. burgdorferi produces surface proteins that are necessary for interactions with the tick or vertebrate tissues it encounters while also repressing the synthesis of unnecessary proteins.

Funder

HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00606-21

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