Scope and Predictive Genetic/Phenotypic Signatures of Bicarbonate (NaHCO 3 ) Responsiveness and β-Lactam Sensitization in Methicillin-Resistant Staphylococcus aureus-Reference-Cited by-同舟云学术

Scope and Predictive Genetic/Phenotypic Signatures of Bicarbonate (NaHCO 3 ) Responsiveness and β-Lactam Sensitization in Methicillin-Resistant Staphylococcus aureus

Published:2020-04-21 Issue:5 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ersoy Selvi C.¹,Otmishi Mariam²,Milan Vanessa T.¹,Li Liang¹,Pak Youngju¹,Mediavilla Jose³,Chen Liang³,Kreiswirth Barry³,Chambers Henry F.⁴,Proctor Richard A.⁵,Xiong Yan Q.¹⁶,Fowler Vance G.⁷,Bayer Arnold S.¹⁶

Affiliation:

1. The Lundquist Institute, Torrance, California, USA

2. California State University Dominguez Hills, Carson, California, USA

3. Meridian Health, Nutley, New Jersey, USA

4. UCSF School of Medicine, San Francisco, California, USA

5. University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

6. Geffen School of Medicine at UCLA, Los Angeles, California, USA

7. Duke University Medical Center, School of Medicine, Durham, North Carolina, USA

Abstract

Addition of sodium bicarbonate (NaHCO 3 ) to standard antimicrobial susceptibility testing medium reveals certain methicillin-resistant Staphylococcus aureus (MRSA) strains to be highly susceptible to β-lactams. We investigated the prevalence of this phenotype (NaHCO 3 responsiveness) to two β-lactams among 58 clinical MRSA bloodstream isolates. Of note, ∼75% and ∼36% of isolates displayed the NaHCO 3 responsiveness phenotype to cefazolin (CFZ) and oxacillin (OXA), respectively.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02445-19

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