Role of the NaHCO <sub>3</sub> Transporter MpsABC in the NaHCO <sub>3</sub> –β-Lactam-Responsive Phenotype in Methicillin-Resistant Staphylococcus aureus-Reference-Cited by-同舟云学术

Role of the NaHCO ₃ Transporter MpsABC in the NaHCO ₃ –β-Lactam-Responsive Phenotype in Methicillin-Resistant Staphylococcus aureus

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Fan Sook-Ha¹^ORCID,Proctor Richard A.²³,Ersoy Selvi C.¹^ORCID,Manna Adhar C.⁴^ORCID,Cheung Ambrose L.⁴,Götz Friedrich⁵^ORCID,Chambers Henry F.⁶,Bayer Arnold S.¹⁷

Affiliation:

1. The Lundquist Institute, Torrance, California, USA

2. Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

3. Department of Medical Microbiology/Immunology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

4. Department of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA

5. Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen, University of Tübingen, Germany

6. UCSF School of Medicine, San Francisco, California, USA

7. Geffen School of Medicine at UCLA, Los Angeles, California, USA

Abstract

MRSA infections are increasingly difficult to treat, due in part to their resistance to most β-lactam antibiotics. A novel and relatively common phenotype, termed NaHCO 3 responsiveness, has been identified in which MRSA strains show increased susceptibility in vitro and in vivo to β-lactams in the presence of NaHCO 3 .

Funder

Deutsche Forschungsgemeinschaft

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00141-23

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