c-di-AMP Is Essential for the Virulence of Enterococcus faecalis-Reference-Cited by-同舟云学术

c-di-AMP Is Essential for the Virulence of Enterococcus faecalis

Published:2021-10-15 Issue:11 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Kundra Shivani¹,Lam Ling Ning¹^ORCID,Kajfasz Jessica K.¹^ORCID,Casella Leila G.¹,Andersen Marissa J.²,Abranches Jacqueline¹^ORCID,Flores-Mireles Ana L.²,Lemos José A.¹^ORCID

Affiliation:

1. Department of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA

2. Department of Biological Sciences, University of Norte Dame, Notre Dame, Indiana, USA

Abstract

Second messenger nucleotides are produced by bacteria in response to environmental stimuli and play a major role in the regulation of processes associated with bacterial fitness, including but not limited to osmoregulation, envelope homeostasis, central metabolism, and biofilm formation. In this study, we uncovered the biological significance of c-di-AMP in the opportunistic pathogen Enterococcus faecalis by isolating and characterizing strains lacking genes responsible for c-di-AMP synthesis ( cdaA ) and degradation ( dhhP and gdpP ).

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Dental and Craniofacial Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00365-21

Reference83 articles.

1. Recent Advances and Current Trends in Nucleotide Second Messenger Signaling in Bacteria

2. Riboswitches in eubacteria sense the second messenger c-di-AMP