Affiliation:
1. Clinical Bacteriology Section, Central Public Health Laboratory, Toronto, Ontario, Canada.
Abstract
One hundred two isolates of methicillin-resistant Staphylococcus aureus (MRSA) randomly selected from across the Canadian province of Ontario were tested for their susceptibility to ciprofloxacin, norfloxacin, and nalidixic acid by the agar dilution method. Forty-nine percent (50 of 102) had high levels of resistance to these quinolone compounds. For the 50 resistant isolates, ciprofloxacin and norfloxacin had high MICs for 90% of isolates (MIC90s) of 128 micrograms/ml and greater than 128 microgram/ml, respectively; for these isolates, the nalidixic acid MIC90 was greater than 640 micrograms/ml. The majority (98%) of the 50 isolates were also resistant to tobramycin (MIC90, greater than 128 micrograms/ml), while 42% of the isolates were resistant to gentamicin (MIC90, 64 micrograms/ml). Quinolone-resistant MRSA isolates were susceptible to bacteriophages from several groups, indicating independent selection of resistant strains. These results suggest that a reappraisal of the use of fluoroquinolones against MRSA in Canada is necessary.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference17 articles.
1. Comparison of the activities of coumermycin, ciprofloxacin, teicoplanin, and other non-,-lactam antibiotics against clinical isolates of methicillin-resistant Staphylococcus aureus from various geographical locations;Aldridge K. E.;Antimicrob. Agents Chemother.,1985
2. Phage typing of staphylococci;Blair J. E.;Bull. W. H. O.,1961
3. Comparative analysis of conjugative plasmids mediating gentamicin resistance in Staphylococcus aureus;Goering R. V.;Antimicrob. Agents Chemother.,1983
4. Harnett N. and C. Krishnan. 1990. Molecular characterization of selected gentamicin- and methicillin-resistant Staphylococcus aureus isolates in Ontario abstr. Gm-17. Abstr. Annu. Meet. Can. Soc. Microbiol. 1990.
5. Quinolones in the hospital-focus on formulary role and cost containment;Jewesson P.;Pharm. Pract,1989
Cited by
60 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献