Gene Sequencing for Routine Verification of Pyrazinamide Resistance in Mycobacterium tuberculosis: a Role for pncA but Not rpsA-Reference-Cited by-同舟云学术

Gene Sequencing for Routine Verification of Pyrazinamide Resistance in Mycobacterium tuberculosis: a Role for pncA but Not rpsA

Published:2012-11 Issue:11 Volume:50 Page:3726-3728
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Alexander David C.¹²,Ma Jennifer H.¹,Guthrie Jennifer L.¹,Blair Joanne¹,Chedore Pam¹,Jamieson Frances B.¹²

Affiliation:

1. Public Health Ontario, Public Health Laboratories, Toronto, Ontario, Canada

2. University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, Ontario, Canada

Abstract

ABSTRACT Pyrazinamide (PZA) is an important component of first-line therapy for the treatment of tuberculosis. Here, we evaluate targeted gene sequencing as a supplement to phenotypic PZA susceptibility testing of Mycobacterium tuberculosis . Routine sequencing of pncA , but not rpsA , is effective for verification of PZA susceptibility results.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00620-12

Reference11 articles.

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