Attenuated Viral Replication of Avian Infectious Bronchitis Virus with a Novel 82-Nucleotide Deletion in the 5a Gene Indicates a Critical Role for 5a in Virus-Host Interactions

Author:

Zhao Ye1,Liang Rong1,Cheng Jinlong1,Zhao Jing1,Xue Jia1,Zhang Guozhong1ORCID

Affiliation:

1. Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China

Abstract

Coronaviruses (CoVs) have a huge impact on humans and animals. It is important for the prevention and control of the viruses to assess the molecular mechanisms related to virulence attenuation.

Funder

MOST | National Key Research and Development Program of China

China Postdoctoral Science Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference44 articles.

1. Coronaviridae: a review of coronaviruses and toroviruses

2. Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome

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4. World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19)

5. King AMQ, Lefkowitz E, Adams MJ, Carstens EB. 2012. Family Flaviviridae, p 1003–1020. In Virus taxonomy: ninth report of the International Committee on Taxonomy of Viruses. Elsevier, Amsterdam, The Netherlands.

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