A Novel Zinc Exporter CtpG Enhances Resistance to Zinc Toxicity and Survival in Mycobacterium bovis

Author:

Chen Liu1,Li Xiaohui2,Xu Piao1,He Zheng-Guo2ORCID

Affiliation:

1. College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China

2. State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Life Science and Technology, Guangxi University, Nanning, China

Abstract

Tuberculosis is caused by the bacillus Mycobacterium tuberculosis and is one of the major sources of mortality. M. tuberculosis has developed unique mechanisms to adapt to host environments, including zinc deficiency and toxicity, during infection. However, the molecular mechanism by which mycobacteria promote detoxification of zinc, and the associated signaling pathways remains largely unclear.

Funder

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Ba-Gui Scholar Program of GuangXi

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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