Quantitative Physiology and Proteome Adaptations of Bifidobacterium breve NRBB57 at Near-Zero Growth Rates

Author:

Ortiz Camargo Angela Rocio1,van Mastrigt Oscar1ORCID,Bongers Roger S.2,Ben-Amor Kaouther2,Knol Jan23,Abee Tjakko1ORCID,Smid Eddy J.1ORCID

Affiliation:

1. Food Microbiology, Wageningen University & Research, Wageningen, The Netherlands

2. Danone Nutricia Research, Utrecht, The Netherlands

3. Laboratory of Microbiology, Wageningen University & Research, Wageningen, The Netherlands

Abstract

In natural environments, nutrients are usually scarce, causing microorganisms to grow slowly while staying metabolically active. In this study we used retentostat cultivation to investigate how the probiotic Bifidobacterium breve adapts its physiology and proteome under severe nutrient limitation resulting in near-zero growth rates (<0.001 h −1 ).

Funder

TKI Agri & Food

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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