Altered Respiratory Microbiomes, Plasma Metabolites, and Immune Responses in Influenza A Virus and Methicillin-Resistant Staphylococcus aureus Coinfection

Author:

Chen Qichao12,Liu Manjiao34,Guo Hao34,Wang Kaiying2,Liu Jiangfeng5,Wang Yun26,Lin Yanfeng12,Li Jinhui2,Li Peihan2,Yang Lang2,Jia Leili2,Yang Juntao5,Li Peng2ORCID,Song Hongbin12

Affiliation:

1. Academy of Military Medical Sciences, Academy of Military Sciences, Beijing, China

2. Center for Disease Control and Prevention of Chinese PLA, Beijing, China

3. State Key Laboratory of Translational Medicine and Innovative Drug Development, Jiangsu Simcere Diagnostics Co., Ltd., Nanjing City, Jiangsu Province, China

4. Nanjing Simcere Medical Laboratory Science Co., Ltd., Nanjing City, Jiangsu Province, China

5. State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China

6. School of Public Health, China Medical University, Shenyang City, Liaoning Province, China

Abstract

The respiratory microbiome plays an important role in respiratory tract infections. In this study, we characterized the URT and LRT microbiota, the host immune response, and plasma metabolic profiles during IAV-MRSA coinfection and evaluated their correlations.

Funder

MOST | National Key Research and Development Program of China

National Science and Technology Major Project

Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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