<i>In Vitro</i> Persistence Level Reflects <i>In Vivo</i> Antibiotic Survival of Natural Pseudomonas aeruginosa Isolates in a Murine Lung Infection Model-Reference-Cited by-同舟云学术

In Vitro Persistence Level Reflects In Vivo Antibiotic Survival of Natural Pseudomonas aeruginosa Isolates in a Murine Lung Infection Model

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Verstraete Laure¹²^ORCID,Aizawa Juliana³^ORCID,Govaerts Matthias³^ORCID,De Vooght Linda³^ORCID,Lavigne Rob⁴^ORCID,Michiels Jan¹²^ORCID,Van den Bergh Bram¹²^ORCID,Cos Paul³^ORCID

Affiliation:

1. Centre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium

2. Center for Microbiology, Flanders Institute for Biotechnology, Leuven, Belgium

3. Laboratory for Microbiology, Parasitology and Hygiene, University of Antwerp, Antwerp, Belgium

4. Laboratory of Gene Technology, KU Leuven, Leuven, Belgium

Abstract

The importance of targeting persister cells in antibiotic therapies is becoming more evident, as these antibiotic-tolerant cells underlie relapsing infections and resistance development. Here, we studied persistence in a clinically relevant pathogen, Pseudomonas aeruginosa .

Funder

EC | Horizon 2020 Framework Programme

Fonds Wetenschappelijk Onderzoek

KU Leuven

Vlaams Instituut voor Biotechnologie

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04970-22

Reference94 articles.