The Linker Region Promotes Activity and Binding Efficiency of Modular LPMO towards Polymeric Substrate-Reference-Cited by-同舟云学术

The Linker Region Promotes Activity and Binding Efficiency of Modular LPMO towards Polymeric Substrate

Published:2022-02-23 Issue:1 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Srivastava Aishwarya¹,Nagar Pragya¹,Rathore Sumit²,Adlakha Nidhi¹^ORCID

Affiliation:

1. Synthetic Biology and Bioprocessing Laboratory, Regional Centre for Biotechnology, NCR-Biotech Cluster, Faridabad, Haryana, India

2. Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India

Abstract

The polysaccharide-disintegrating carbohydrate-active enzymes (CAZymes) are often found with multimodular architecture, where the catalytic domain is connected to an accessory CBM domain with the help of a flexible linker region. So far, the linker has been understood merely as a flexible spacer between the two domains.

Funder

DST-INSPIR

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02697-21

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