Noncanonical Mismatch Repair Protein NucS Modulates the Emergence of Antibiotic Resistance in Mycobacterium abscessus-Reference-Cited by-同舟云学术

Noncanonical Mismatch Repair Protein NucS Modulates the Emergence of Antibiotic Resistance in Mycobacterium abscessus

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Fressatti Cardoso Rosilene¹,Martín-Blecua Isabel²,Pietrowski Baldin Vanessa¹,Meneguello Jean Eduardo¹,Valverde José Ramón³,Blázquez Jesús²,Castañeda-García Alfredo²^ORCID

Affiliation:

1. Departamento de Análises Clínicas e Biomedicina, Universidade Estadual de Maringá, Maringá, Paraná, Brazil

2. Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología CNB-CSIC, Madrid, Spain

3. Departamento de Computación Científica, Centro Nacional de Biotecnología CNB-CSIC, Madrid, Spain

Abstract

Chronic infections caused by M. abscessus are an emerging challenge in public health, posing a substantial health and economic burden, especially in patients with cystic fibrosis. Treatment of M. abscessus infections with antibiotics is particularly challenging, as its complex drug resistance mechanisms, including constitutive resistance through DNA mutation, lead to high rates of treatment failure.

Funder

Ministerio de Ciencia, Innovación y Universidades

MEC | Instituto de Salud Carlos III

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02228-22

Reference62 articles.

1. Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus