Expression of Human Endogenous Retrovirus Group K (HERV-K) HML-2 Correlates with Immune Activation of Macrophages and Type I Interferon Response-Reference-Cited by-同舟云学术

Expression of Human Endogenous Retrovirus Group K (HERV-K) HML-2 Correlates with Immune Activation of Macrophages and Type I Interferon Response

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Russ Eric¹²³^ORCID,Mikhalkevich Natallia¹²,Iordanskiy Sergey¹⁴^ORCID

Affiliation:

1. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

2. The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA

3. Graduate Program of Cellular and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

4. Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

Abstract

The human endogenous retrovirus group K subgroup, HML-2, is known to be elevated in a long list of inflammation-associated diseases. However, a clear mechanism for HML-2 upregulation in response to inflammation has not been defined.

Funder

DOD | USA | MEDCOM | Congressionally Directed Medical Research Programs

DOD | USU | Armed Forces Radiobiology Research Institute, Uniformed Services University

DOD | Uniformed Services University of the Health Sciences

The American Genome Research Center

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04438-22

Reference81 articles.

1. Retroelements and the human genome: New perspectives on an old relation

2. Identification of the distribution of human endogenous retroviruses K (HML-2) by PCR-based target enrichment sequencing

3. Expression of endogenous retroviruses reflects increased usage of atypical enhancers in T cells

4. Human endogenous retrovirus HERV-K(HML-2) activity in prostate cancer is dominated by a few loci

5. Expression of human endogenous retrovirus HERV-K18 superantigen is elevated in juvenile rheumatoid arthritis;Sicat J;J Rheumatol,2005

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