Complete Genetic Analysis of Plasmids Carried by Two Nonclonal bla NDM-5 - and mcr-1 -Bearing Escherichia coli Strains: Insight into Plasmid Transmission among Foodborne Bacteria-Reference-Cited by-同舟云学术

Complete Genetic Analysis of Plasmids Carried by Two Nonclonal bla NDM-5 - and mcr-1 -Bearing Escherichia coli Strains: Insight into Plasmid Transmission among Foodborne Bacteria

Published:2021-10-31 Issue:2 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Liu Xiaobo¹,Li Ruichao²^ORCID,Dong Ning³,Ye Lianwei³,Chan Edward Wai-Chi⁴,Chen Sheng³^ORCID

Affiliation:

1. Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute, Shenzhen, People’s Republic of China

2. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, People’s Republic of China

3. Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong SAR

4. The State Key Lab of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR

Abstract

Carbapenem and colistin are last-resort antibiotics used to treat serious clinical infections caused by multidrug-resistant (MDR) bacterial pathogens. Plasmids encoding resistance to carbapenems and colistin have been reported in clinical pathogens in recent years, and yet few studies reported cocarriage of mcr and bla NDM genes in Escherichia coli strains of food origin.

Funder

Hong Kong Research Grant Council Collaborative Research Fund

Priority Academic Program Development of Jiangsu Higher Education Institutions

Guangdong major project of basic and applied basic research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.00217-21

Reference12 articles.

1. Polymyxin Combinations Combat Escherichia coli Harboring mcr-1 and bla NDM-5 : Preparation for a Postantibiotic Era