New Variant of mcr-3 in an Extensively Drug-Resistant Escherichia coli Clinical Isolate Carrying mcr-1 and bla NDM-5-Reference-Cited by-同舟云学术

New Variant of mcr-3 in an Extensively Drug-Resistant Escherichia coli Clinical Isolate Carrying mcr-1 and bla NDM-5

Published:2017-12 Issue:12 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Liu Lu¹²,Feng Yu¹²,Zhang Xiaoxia¹²,McNally Alan³,Zong Zhiyong¹²⁴⁵

Affiliation:

1. Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China

2. Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China

3. Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

4. Department of Infection Control, West China Hospital, Sichuan University, Chengdu, China

5. Center for Pathogen Research, West China Hospital, Sichuan University, Chengdu, China

Abstract

ABSTRACT A colistin- and carbapenem-resistant Escherichia coli clinical isolate was found to carry two plasmid-borne colistin-resistant genes, mcr-1 and the newly identified mcr-3 , and a carbapenemase gene, bla NDM-5 . mcr-3 is a new variant ( mcr-3.5 ) in the isolate and encodes three amino acid substitutions compared with the original MCR-3. mcr-3 was carried by a Tn As3 -like transposon on a self-transmissible IncP plasmid in the isolate, highlighting that mcr-3 may have widely spread.

Funder

National Natural Science Foundation of China

Royal Society

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01757-17

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