Genomic and Phenotypic Trait Variation of the Opportunistic Human Pathogen Aspergillus flavus and Its Close Relatives-Reference-Cited by-同舟云学术

Genomic and Phenotypic Trait Variation of the Opportunistic Human Pathogen Aspergillus flavus and Its Close Relatives

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Hatmaker E. Anne¹²^ORCID,Rangel-Grimaldo Manuel³,Raja Huzefa A.³^ORCID,Pourhadi Hadi³,Knowles Sonja L.³,Fuller Kevin⁴,Adams Emily M.⁴,Lightfoot Jorge D.⁴,Bastos Rafael W.⁵,Goldman Gustavo H.⁶^ORCID,Oberlies Nicholas H.³^ORCID,Rokas Antonis¹²^ORCID

Affiliation:

1. Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA

2. Evolutionary Studies Initiative, Vanderbilt University, Nashville, Tennessee, USA

3. Department of Chemistry & Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina, USA

4. Department of Microbiology and Immunology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA

5. Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil

6. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil

Abstract

Aspergillus flavus is a filamentous fungus that causes opportunistic human infections, such as aspergillosis and fungal keratitis, but its close relatives are considered nonpathogenic. To begin understanding how this difference in pathogenicity evolved, we characterized variation in infection-relevant genomic, chemical, and phenotypic traits between strains of A. flavus and its relatives.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

National Science Foundation

Burroughs Wellcome Fund

HHS | NIH | National Eye Institute

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03069-22

Reference137 articles.