Genetic Characterization of a Conjugative Plasmid That Encodes Azithromycin Resistance in <i>Enterobacteriaceae</i>-Reference-Cited by-同舟云学术

Genetic Characterization of a Conjugative Plasmid That Encodes Azithromycin Resistance in Enterobacteriaceae

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Liu Xiaoxuan¹^ORCID,Yang Xuemei¹,Ye Lianwei¹,Chan Edward Wai-Chi²,Chen Sheng¹^ORCID

Affiliation:

1. Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong

2. State Key Lab of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong

Abstract

In this study, we identified a conjugative plasmid carrying a novel azithromycin resistance gene, erm (42), from a clinical K. pneumoniae strain. Conjugation of this plasmid into Salmonella conjugants conferred resistance to azithromycin, which is considered a choice for treating Salmonella infections.

Funder

National Natural Science Foundation of China and Research Grand Council of Government of Hong Kong SAR

Guangdong Major Project of Basic and Applied Basic Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00788-22

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