Clinical Evaluation of Metagenomic Next-Generation Sequencing Method for the Diagnosis of Suspected Ascitic Infection in Patients with Liver Cirrhosis in a Clinical Laboratory-Reference-Cited by-同舟云学术

Clinical Evaluation of Metagenomic Next-Generation Sequencing Method for the Diagnosis of Suspected Ascitic Infection in Patients with Liver Cirrhosis in a Clinical Laboratory

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Wu Hao-Xin¹^ORCID,Wei Fei-Li²,Zhang Wei¹,Han Jie¹,Guo Shan²,Wang Zheng¹,Chen De-Xi²,Hou Wei¹,Hu Zhong-Jie¹^ORCID

Affiliation:

1. Beijing YouAn Hospital, Capital Medical University, Beijing, China

2. Beijing Institute of Hepatology, Beijing YouAn Hospital, Capital Medical University, Beijing Precision Medicine and Transformation Engineering Technology Research Center of Hepatitis and Liver Cancer, Beijing, China

Abstract

This study established and evaluated a complete metagenomics next-generation sequencing assay to improve the diagnosis of suspected ascitic infection in a clinical laboratory affiliated with a hospital. The assay is superior to traditional culture testing and will aid in the early and accurate identification of pathogens, particularly in patients with polymicrobial infections.

Funder

Beijing Municipal Science and Technology Commission

Ministry of Health of China | Wu Jieping Medical Foundation

BMHB | Capital Health Research and Development of Special Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02946-22

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1. Chinese guidelines on the management of ascites in cirrhosis;Hepatology International;2024-07-09

2. Application of metagenomic next-generation sequencing in optimizing the diagnosis of ascitic infection in patients with liver cirrhosis;BMC Infectious Diseases;2024-05-20

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