Landscape of Exhausted T Cells in Tuberculosis Revealed by Single-Cell Sequencing-Reference-Cited by-同舟云学术

Landscape of Exhausted T Cells in Tuberculosis Revealed by Single-Cell Sequencing

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Pan Jiahui¹,Zhang Xinyue¹,Xu Jianting²,Chang Zecheng¹,Xin Zhuoyuan¹,Wang Guoqing¹^ORCID

Affiliation:

1. Key Laboratory of Zoonosis Research, Ministry of Education, College of Basic Medical Science, Jilin University, Changchun, China

2. The First Hospital of Jilin University, Changchun, China

Abstract

Identifying the changes in immune cells in response to infection can provide a better understanding of the effects of Mycobacterium tuberculosis on the host immune system. We performed single-cell RNA-sequencing analysis of CD4 + T and CD8 + T cells isolated from peripheral blood mononuclear cells of healthy individuals and patients with tuberculosis to reveal the cellular characteristics.

Funder

National Natural Science Foundation of China

The Youth Science and Technology Innovation Leader Team | Project of the Science and Technology Department of Jilin Province

The Science and Technology Research Project of the Education Department of Jilin Province

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02839-22

Reference45 articles.

1. The global tuberculosis epidemic and progress in care, prevention, and research: an overview in year 3 of the End TB era